Fibroblast Growth Factor - 23 and Incident Atrial Fibrillation : The Multi - Ethnic Study of Atherosclerosis ( MESA ) and the Cardiovascular Health Study ( CHS ) Running title :
نویسندگان
چکیده
Division of Cardiology, University of Washington, Seattle, WA; Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA; Cardiovascular Health Research Unit, Depts of Medicine and Epidemiology, University of Washington, Seattle, WA; Dept of Epidemiology, University of Washington, Seattle, WA; Dept of Laboratory Medicine, University of Washington, Seattle, WA; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; Division of Cardiology, Electrophysiology Section, University of Pennsylvania, Philadelphia, PA; Division of Nephrology and Hypertension, Dept of Medicine, University of California San Diego, and San Diego VA Healthcare System, San Diego, CA
منابع مشابه
Fibroblast growth factor-23 and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS).
BACKGROUND Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism. Circulating FGF-23 concentrations increase markedly in chronic kidney disease and are associated with increased risk of clinical cardiovascular events. FGF-23 may promote atrial fibrillation (AF) by inducing left ventricular hypertrophy and diastolic and lef...
متن کاملEffect of High Intensity Interval Training on the Level of Atrial Fibrillation, Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure
Introduction: Cardiovascular problems and atrial fibrillation is one of the most prevalent secondary consequences in hemodialysis patients. This study aimed to examine the effect of high intensity interval training on the level of atrial fibrillation, fibroblast growth factor 23 and Klotho in male rats with chronic kidney disease. Methods: In this study, 30 male rats Wistar (7-8 weeks) were ra...
متن کاملCardiac Magnetic Resonance-Measured Left Atrial Volume and Function and Incident Atrial Fibrillation: Results From MESA (Multi-Ethnic Study of Atherosclerosis).
BACKGROUND Early detection of structural changes in left atrium (LA) before atrial fibrillation (AF) development could be helpful in identification of those at higher risk for AF. Using cardiac magnetic resonance imaging, we examined the association of LA volume and function, and incident AF in a multiethnic population free of clinical cardiovascular diseases. METHODS AND RESULTS In a case-co...
متن کاملFibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis.
BACKGROUND Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory hormone that directly stimulates left ventricular hypertrophy in experimental models. The role of FGF-23 in cardiovascular disease development in the general population is unclear. We tested associations of FGF-23 with major subclinical and clinical cardiovascular disease outcomes in a large prospective cohort. METHODS ...
متن کاملRight Ventricular Structure and Function Are Associated With Incident Atrial Fibrillation: MESA-RV Study (Multi-Ethnic Study of Atherosclerosis-Right Ventricle).
BACKGROUND Right ventricular (RV) morphology has been associated with drivers of atrial fibrillation (AF) risk, including left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation. The aim of this study was to investigate the association between RV morphology and risk of incident AF. METHODS AND RESULTS We interpreted cardiac magnetic resonance imaging in 4...
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